Combining epidemiology and radiobiology to assess cancer risks in the breast, lung, thyroid and digestive tract after exposures to ionizing radiation with total doses in the order of 100 mSv or below
WELCOME
The main aim of EpiRadBio is to combine epidemiology and radiobiology to assess cancer risks in the breast, lung, thyroid and digestive tract after exposures to ionizing radiation with cumulated equivalent doses of the order of 100 mSv or below. Such exposures are of central importance for radiation protection, since they correspond to
- the dose limit for occupational exposure (100 mSv in five years)
- exposures currently occurring in the work place (generally below 100 mSv over lifetime)
- exposures currently occurring due to medical diagnostics, e.g. by a number of CT examinations (up to the order of 100 mSv).
In order to supply a new basis for the risk assessment underlying current radiation protection, the key objectives of EpiRadBio are to
- perform measurements of telomere lengths, array-based comparative genomic hybridisation and other ‘omics’ with cancer tissue and blood samples from members of outstanding radioepidemiological cohorts in order to characterize key processes of carcinogenesis in humans exposed to low dose radiation
- analyze radiation responses of stem cells and low dose perturbation of intercellular communication in 2D and 3D models using human, normal breast and lung epithelial cells in order to elucidate further key processes of carcinogenesis and supplement the studies of samples from epidemiological cohorts
- integrate the new radiobiological results in models of carcinogenesis in order to include this knowledge in an evaluation of key epidemiological data
- derive cancer risks including individual risk factors after exposures with cumulative equivalent doses of the order of 100 mSv or below for supporting radiation protection.

Logo
Combining epidemiology and radiobiology to assess cancer risks in the breast, lung, thyroid and digestive tract after exposures to ionizing radiation with total doses in the order of 100 mSv or below
Fission-2010-3.1.1
Contribution to low-dose risk research in Europe
Collaborative project
Large scale  integrating project