Combining epidemiology and radiobiology to assess cancer risks in the breast, lung, thyroid and digestive tract after exposures to ionizing radiation with total doses in the order of 100 mSv or below
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Combining epidemiology and radiobiology to assess cancer risks in the breast, lung, thyroid and digestive tract after exposures to ionizing radiation with total doses in the order of 100 mSv or below
First Periodic Report - Summary

Project context and objectives
The main aim of EpiRadBio is to combine epidemiology and radiobiology to assess cancer risks in the breast, lung, thyroid and digestive tract after exposures to ionizing radiation with cumulated equivalent doses of the order of 100 mSv or below. Such exposures are of central importance for radiation protection, since they correspond to
• the dose limit for occupational exposure (100 mSv in five years)
• exposures currently occurring in the work place (generally below 100 mSv over lifetime)
• exposures currently occurring due to medical diagnostics, e.g, by CT scans causing equivalent doses in the order of 10 mSv per examinations
While most of these exposures are from low-LET radiation, also exposures to high-LET radiation occur. Thus, EpiRadBio will explore cancer risks not only from the important types of low-LET radiation but also from alpha radiation. It is of urgent importance to analyse these cancer risks, because...
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Second Priodic Report

Project objectives, work progress and achievements, project management
In order to supply a new basis for the risk assessment underlying current radiation protection, the key objectives of EpiRadBio are to
• perform measurements of telomere lengths, array-based comparative genomic hybridisation and other ‘omics’ with cancer tissue and blood samples from members of outstanding radioepidemiological cohorts in order to characterize key processes of carcinogenesis in humans exposed to low dose radiation
• analyse radiation responses of stem cells and low dose perturbation of intercellular communication in 2D and 3D models using human, normal breast and lung epithelial cells in order to elucidate further key processes of carcinogenesis and supplement the studies of samples from epidemiological cohorts
• integrate the new radiobiological results in models of carcinogenesis in order to include this knowledge in an evaluation of key epidemiological data
• derive cancer risks including individual risk factors after exposures with cumulative equivalent doses of the order of 100 mSv or below for supporting radiation protection.
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