Combining epidemiology and radiobiology to assess cancer risks in the breast, lung, thyroid and digestive tract after exposures to ionizing radiation with total doses in the order of 100 mSv or below
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Combining epidemiology and radiobiology to assess cancer risks in the breast, lung, thyroid and digestive tract after exposures to ionizing radiation with total doses in the order of 100 mSv or below
Publications of EpiRadBio
1.    Alloni Daniele, Track structure, radiation quality and initial radiobiological events: Considerations based on the PARTRAC code experience, The International Journal of Radiation Biology, 2012, Vol. 88, No. 1-2, 77-86, doi: 10.3109/09553002.2011.627976
2.    Alloni Daniele, Integration of Monte Carlo simulations with PFGE experimental data on DNA double strand breaks induced by nitrogen ions shows a RBE compatible to γ-H2AX results, Radiation Research, 2013, 179(6), 690-697, doi: 10.1667/R3043.1
3.    Alloni Daniele, Early Events Leading to Radiation-Induced Biological Effects, Comprehensive Biomedical Physics, 2014, Vol. 7, 1-22
4.    G. Babini, M. Ugolini, J. Morini, G. Baiocco, L. Mariotti, P. Tabarelli de Fatis, M. Liotta, A. Ottolenghi, Investigation of radiation-induced multilayered signaling response of the inflammatory pathway, Radiat. Prot. Dos (2015) doi:10.1093/rpd/ncv132
5.    G. Babini, V. E. Bellinzona, J. Morini, L. Mariotti, K. Unger, A. Ottolenghi , Mechanisms of the induction of apoptosis mediated by radiation-induced cytokine release, Radiat. Prot. Dos. (2015) doi:10.1093/rpd/ncv133.
6.    Candela-Juan C , Karlsson M, Lundell M, Ballester F, Carlsson Tedgren Å, Dosimetric characterization of two radium sources for retrospective dosimetry studies. Med Phys 2015;42(5):2132-2142.  
7.    Eidemüller M, E. Holmberg, P. Jacob, M. Lundell, P. Karlsson, Breast cancer risk and possible mechanisms of radiation-induced genomic instability in the Swedish hemangioma cohort after reanalyzed dosimetry, Mutation Research 775 (2015) 1–9.
8.    Giulotto E,  More on the Lack of Correlation between Terra Expression and Telomere Length, Front Oncol., 2013, Vol 3, 245, doi: 10.3389/fonc.2013.00245
9.    Giulotto E, TERRA Expression Levels Do Not Correlate with Telomere Length and Radiation Sensitivity in Human Cancer Cell Lines. Front Oncol, 2013, Vol 3, doi: 10.3389/fonc.2013.00115
10.    Jacob Peter,  Jan Christian Kaiser, and Alexander Ulanovsky Ultrasonography survey and thyroid cancer in the Fukushima Prefecture Radiat Environ Biophys. 2014; 53: 391–401. Published online Jan 9, 2014. doi: 10.1007/s00411-013-0508-3 PMCID: PMC3996282
11.    Kaiser JC, Meckbach R, Jacob P (2014) Genomic Instability and Radiation Risk in Molecular Pathways to Colon Cancer. PLoS ONE 9(10): e111024. doi:10.1371/journal.pone.0111024
12.    Kavanagh, JN., Redmond, KM.,. Schettino, G., and Prise, KM, DNA Double Strand Break Repair: A Radiation Perspective, Antioxidants & Redox Signaling, Volume 18, Mary Ann  Liebert Inc, New York, 2013, 2458-2472, doi: 10.1089/ars.2012.5151.
13.    Kevin M. Prise, Anna Saran, Concise Review: Stem Cell Effects in Radiation Risk, STEM CELLS 29,1315–1321, (2011).
14.    Kundrát P, W. Friedland: Impact of intercellular induction of apoptosis on low-dose radiation carcinogenesis. Radiation Protection Dosimetry, DOI: 10.1093/rpd/ncv169
15.    Lundell M, Karlsson M, Carlsson Tedgren Å. New dosimetry for childhood skin hemangioma treatments with 226Ra needles or tubes. Radiother Oncol. 2015 Jun 20. pii: S0167-8140(15)00296-0. doi: 10.1016/j.radonc.2015.06.014.
16.    Manda K, Kavanagh JN, Buttler D, Prise KM, Hildebrandt G; Low dose effects of ionizing radiation on normal tissue stem cells. Mutat Res Rev Mutat Res. 2014 Feb 22. pii: S1383-5742(14)00017-9. doi: 10.1016/j.mrrev.2014.02.003.
17.    Manesh, Sara Shakeri, Traimate Sangsuwan1, Andrzej Wojcik, Siamak Haghdoost, Studies of adaptive response and mutation induction in MCF-10A cells following exposure to chronic or acute ionizing radiation; Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Volume 780, October 2015, Pages 55–59, doi:10.1016/j.mrfmmm.2015.07.008
18.    L.G. Mariotti, A.B. Abdelrazzak, A. Ottolenghi, P. O'Neill and M.A. Hill, Stimulation of intercellular induction of apoptosis in transformed cells at very low doses of ionising radiation: spatial and temporal features. Radiat. Prot. Dosim. (2015) doi: 10.1093/rpd/ncv176
19.    Selmansberger M, A Feuchtinger, L Zurnadzhy, A Michna, J C Kaiser, M Abend, A Brenner, T Bogdanova, A Walch, K Unger, H Zitzelsberger and J Hess. CLIP2 as radiation biomarker in papillary thyroid carcinoma. Oncogene , (6 October 2014) | doi:10.1038/onc.2014.311
20.    Selmansberger M, Kaiser JC, Hess J, Guethlin D, Likhtarov I, Shpak V, et al. Dose-dependent expression of CLIP2 in post-Chernobyl papillary thyroid carcinomas. Carcinogenesis. 2015. doi: 10.1093/carcin/bgv043. PubMed PMID: 25957251.
21.    Shim, G., Ricoul, M., Hempel WM, Azzam El, Sabatier L, Crosstalk between telomere maintenance and radiation effects: A key player in the process of radiation-induced carcinogenesis. Mutation Research, 2014, 1-17, doi: 10.1016/j.mrrev.2014.01.001
22.    Smirnova A, Gamba R, Khoriauli L, Vitelli V, Nergadze SG, Giulotto E. TERRA Expression Levels Do Not Correlate with Telomere Length and Radiation Sensitivity in Human Cancer Cell Lines. Front Oncol. 2013 May 10;3:115.
23.    Vitelli V, Falvo P, Khoriauli L, Smirnova A, Gamba R, Santagostino M, Nergadze SG, Giulotto E. More on the Lack of Correlation between Terra Expression and Telomere Length. Front Oncol. 2013 Sep 18;3:245. eCollection 2013
24. Integration of a radiation biomarker into modelling of thyroid carcinogenesis and post-Chernobyl risk assessment, Jan Christian Kaiser, Reinhard Meckbach, Markus Eidemuller, Martin Selmansberger, Kristian Unger, Viktor Shpak, Maria Blettner, Horst Zitzelsbergerand Peter Jacob, Carcinogenesis, 2016, Vol. 37, No. 12, 1152–1160, doi:10.1093/carcin/bgw102
25. Mechanistic study on lung cancer mortality after radon exposure in the Wismut cohort supports important role of clonal expansion in lung carcinogenesis. I. Zaballa, M. Eidemuller, Radiat Environ Biophys (2016) 55:299–315, DOI 10.1007/s00411-016-0659-0

In press

1.    Frenzel M. Cuceu C., Shim G., Ricoul M. and Sabatier L, Encyclopedia of Pathology, Springer, 2015, in press
2.    Kavanagh JN, Waring EJ, Prise KM. Radiation Responses of Stem Cells: Targeted and Non-Targeted Effects. Radiat Prot Dosimetry. 2015 Apr 15. pii: ncv161. [Epub ahead of print] PubMed PMID: 25877536.
3.    van Wieringen, W.N., & Peeters, C.F.W. (under review). Ridge estimation of inverse covariance matrices from high-dimensional data, Publicly available as arXiv:1403.0904 [stat.ME] at http://arxiv.org/abs/1403.0904
4.    S. Zöllner, M. E. Sokolnikov, and M. Eidemüller. (2015) Beyond two-stage models for lung carcinogenesis in the Mayak workers: Implications for Plutonium risk. PLOS ONE (in print)

Submitted

1.    Acheva Anna, Eklund Elina, Lemola Elina, Siiskonen Teemu, Launonen Virpi and Kämäräinen Meerit. Lack of epithelial-to-mesenchymal transition induction in two bronchial epithelial cell lines after alpha and gamma irradiation. Submitted
2.    Lundell M, Karlsson M, Carlsson Tedgren Å, New dosimetry for childhood skin hemangioma with 226Ra needles and tubes.  Submitted march 2015
3.    Sara Shakeri Manesh, Traimate Sangsuwan, Andrzej Wojcik and Siamak Haghdoost. Studies of adaptive response and mutation induction in the chronically and acutely exposed MCF-10A cells to ionising radiation. Manuscript is under review. Mutation Research
4.    Siamak Haghdoost, Studies of adaptive response and mutation induction in the chronically and acutely exposed MCF-10A cells to ionising radiation, Mutation research
In preparation
1.    Abdelrazzak, AB, Pottgießer, S, Hill, MA, O`Neill, P and Bauer, G Enhancement of peroxidase release from non-malignant and malignant cells through low-dose irradiation with different radiation quality.
2.    Anna Acheva, Siamak Haghdoost, Alice Sollazzo, Virpi Launonen and Meerit Kämäräinen, Presence of stromal cells enhances EMT induction in lung bronchial epithelium after protracted exposure to gamma radiation. Manuscript is ready for submission
3.    Bilgrau, A.E., Peeters, C.F.W., Eriksen, P.S., Bøgsted, M., & van Wieringen, W.N. (near completion). Targeted fused ridge estimation of multiple inverse class covariance matrices from high-dimensional data.
4.    Eidemüller M, Holmberg E, Jacob P, Lundell M, Karlsson P, Radiation induced breast cancer risk in the Swedish hemangioma cohort taking into account breast cancers among mothers, sisters and daugthers.
5.    G. Babini, K. Unger, J. Morini, G. Baiocco, H. Zitzelsberger, A. Ottolenghi, Mechanisms of cytokine-mediated pro-apoptotic effects of irradiated normal cells on non-irradiated transformed cells.
6.    Kundrát P et al, Low-dose radiation enhances the intercellular induction of apoptosis in oncogenic transformed cells in vitro but is predicted to reduce this anti-carcinogenic process in vivo.
7.    Kundrát P et al, Modelling the time- and space-dependent signalling underlying the intercellular induction of apoptosis in oncogenic transformed cells.
8.    Liddle D, McGuire A, Mariotti LG, Ottolenghi A, O’Neill P, Hill MA, Generality of intercellular induction of apoptosis through enhanced oxidative stress stimulated by low dose radiation.
9.    Liddle, D, McGuire ,A,  Mariotti LG, Ottolenghi A,  O’Neill P,  Hill MA  Generality of the modification of intercellular signalling following irradiation of normal human lung and breast epithelial cells and the role of oxidative stress.
10.    Mariotti LG, Abdelrazzak A, Liddle, D, McGuire, A. Ottolenghi A, Vojnovic, B., O’Neill P,  Hill MA Spatial and temporal features of apoptotic induction in pre-cancerous cells modulated by radiation.  
11.    Peeters, C.F.W., van de Wiel, M.A., & van Wieringen, W.N. (near completion). The spectral condition number plot for regularization parameter determination.
12.    Rubino C, Allodji R, Schvarz C, Andruccioli M, Bardet S, Henry-Amar M, Le Thai F, Corone K, Lönn S,  Hall P, Lamart S, Diallo I, Ricard M, Schlumberger M, de Vathaire F. European cohort of Differentiated Thyroid Cancer (DTC): Risk of secondary breast cancer according to the treatments.
13.    Sokolnikov M, Manuscript on breast cancer among Mayak workers