Combining epidemiology and radiobiology to assess cancer risks in the breast, lung, thyroid and digestive tract after exposures to ionizing radiation with total doses in the order of 100 mSv or below
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Combining epidemiology and radiobiology to assess cancer risks in the breast, lung, thyroid and digestive tract after exposures to ionizing radiation with total doses in the order of 100 mSv or below
Publications of EpiRadBio

1.    Abdelrazzak, AB, Pottgießer, S, Hill, MA, O`Neill, P and Bauer, G Enhancement of peroxidase release from non-malignant and malignant cells through low-dose irradiation with different radiation quality. Radiat Res 185, 199–213 (2016)
2.    Acheva Anna, Eklund Elina, Lemola Elina, Siiskonen Teemu, Launonen Virpi and Kämäräinen Meerit. Lack of epithelial-to-mesenchymal transition induction in two bronchial epithelial cell lines after alpha and gamma irradiation. Int. J. of Low Radiation, 2015 Vol.10, No.2, pp.116 – 133, DOI:10.1504/IJLR.2015.074411.
3.    Alloni Daniele, Track structure, radiation quality and initial radiobiological events: Considerations based on the PARTRAC code experience, The International Journal of Radiation Biology, 2012, Vol. 88, No. 1-2, 77-86, doi: 10.3109/09553002.2011.627976.
4.    Alloni Daniele, Integration of Monte Carlo simulations with PFGE experimental data on DNA double strand breaks induced by nitrogen ions shows a RBE compatible to γ-H2AX results, Radiation Research, 2013, 179(6), 690-697, doi: 10.1667/R3043.1.
5.    Alloni Daniele, Early Events Leading to Radiation-Induced Biological Effects, Comprehensive Biomedical Physics, 2014, Vol. 7, 1-22
6.    G. Babini, M. Ugolini, J. Morini, G. Baiocco, L. Mariotti, P. Tabarelli de Fatis, M. Liotta, A. Ottolenghi, Investigation of radiation-induced multilayered signaling response of the inflammatory pathway, Radiat. Prot. Dos (2015) doi:10.1093/rpd/ncv132
7.    G. Babini, V. E. Bellinzona, J. Morini, L. Mariotti, K. Unger, A. Ottolenghi , Mechanisms of the induction of apoptosis mediated by radiation-induced cytokine release, Radiat. Prot. Dos. (2015) doi:10.1093/rpd/ncv133.
8.    Bilgrau, A.E., Peeters, C.F.W., Eriksen, P.S., Bøgsted, M., & van Wieringen, W.N. Targeted fused ridge estimation of multiple inverse class covariance matrices from high-dimensional data. arXiv:1509.07982v1 [stat.ME] 26 Sep 2015
9.    Candela-Juan C, Karlsson M, Lundell M, Ballester F, Carlsson Tedgren Å, Dosimetric characterization of two radium sources for retrospective dosimetry studies. Med Phys 2015;42(5):2132-2142.
10.    Eidemüller M, E. Holmberg, P. Jacob, M. Lundell, P. Karlsson, Breast cancer risk and possible mechanisms of radiation-induced genomic instability in the Swedish haemangioma cohort after re-analysed dosimetry, Mutation Research 775 (2015) 1–9.
11.    Eidemüller M, Holmberg E, Jacob P, Lundell M, Karlsson P, Radiation induced breast cancer risk in the Swedish haemangioma cohort taking into account breast cancers among mothers, sisters and daughters. Mutation Research, 11 Mar 2015, 775:1-9, DOI:10.1016/j.mrfmmm.2015.03.002
12.    Frenzel M. Cuceu C., Shim G., Ricoul M. and Sabatier L, Encyclopaedia of Pathology, Springer, 2015, Series Ed.:van Krieken, J. H. J. M., ISSN:2366-6269
13.    Giulotto E,  More on the Lack of Correlation between Terra Expression and Telomere Length, Front Oncol., 2013, Vol 3, 245, doi: 10.3389/fonc.2013.00245.
14.    Giulotto E, TERRA Expression Levels Do Not Correlate with Telomere Length and Radiation Sensitivity in Human Cancer Cell Lines. Front Oncol, 2013, Vol 3, doi: 10.3389/fonc.2013.00115
15.    Jacob Peter, Jan Christian Kaiser, and Alexander Ulanovsky Ultrasonography survey and thyroid cancer in the Fukushima Prefecture Radiat Environ Biophys. 2014; 53: 391–401. Published online Jan 9, 2014. doi: 10.1007/s00411-013-0508-3 PMCID: PMC3996282.
16.    . Kaiser JC, Meckbach R, Jacob P (2014) Genomic Instability and Radiation Risk in Molecular Pathways to Colon Cancer. PLoS ONE 9(10): e111024. doi: 10.1371/journal.pone.0111024.
17.    Kavanagh, JN., Redmond, KM. Schettino, G., and Prise, KM, DNA Double Strand Break Repair: A Radiation Perspective, Antioxidants & Redox Signaling, Volume 18, Mary Ann Liebert Inc, New York, 2013, 2458-2472, doi: 10.1089/ars.2012.5151.
18.    Kavanagh, J. N., Waring, E. J., & Prise, K. M. (2015). Radiation responses of stem cells: targeted and nottargeted effects. Radiation Protection Dosimetry, 166(1-4), 110-117. DOI: 10.1093/rpd/ncv161.
19.    Kevin M. Prise, Anna Saran, Concise Review: Stem Cell Effects in Radiation Risk, STEM CELLS 29,1315–1321, (2011).
20.    Kundrát P, W. Friedland: Impact of intercellular induction of apoptosis on low-dose radiation carcinogenesis. Radiation Protection Dosimetry, DOI: 10.1093/rpd/ncv169.
21.    Kundrát P, Friedland W., Enhanced release of primary signals may render intercellular signalling ineffective due to spatial aspects. Sci Rep. 2016 Sep 20; 6:33214. doi: 10.1038/srep33214.
22.    Lundell M, Karlsson M, Carlsson Tedgren Å, New dosimetry for childhood skin hemangioma with 226Ra needles and tubes. Radiother Oncol. 2015 Jul;116(1):139-42. doi: 10.1016/j.radonc.2015.06.014. Epub 2015 Jun 21.
23.    Lundell M, Karlsson M, Carlsson Tedgren Å. New dosimetry for childhood skin hemangioma treatments with 226Ra needles or tubes. Radiother Oncol. 2015 Jul;116(1):139-42. doi: 10.1016/j.radonc.2015.06.014. Epub 2015 Jun 21.
24.    Manda K, Kavanagh JN, Buttler D, Prise KM, Hildebrandt G; Low dose effects of ionizing radiation on normal tissue stem cells. Mutat Res Rev Mutat Res. 2014 Feb 22. pii: S1383-5742(14)00017-9. doi: 10.1016/j.mrrev.2014.02.003.
25.    Manesh, Sara Shakeri, Traimate Sangsuwan, Andrzej Wojcik, Siamak Haghdoost, Studies of adaptive response and mutation induction in MCF-10A cells following exposure to chronic or acute ionizing radiation; Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, Volume 780, October 2015, Pages 55–59, doi: 10.1016/j.mrfmmm.2015.07.008.
26.    Manesh, Sara Shakeri, Traimate Sangsuwan, Andrzej Wojcik and Siamak Haghdoost. Studies of adaptive response and mutation induction in the chronically and acutely exposed MCF-10A cells to ionising radiation. (2015) Mutation research, ISSN 0027-5107, E-ISSN 1873-135X, Vol. 780, 55-59
27.    L.G. Mariotti, A.B. Abdelrazzak, A. Ottolenghi, P. O'Neill and M.A. Hill, Stimulation of intercellular induction of apoptosis in transformed cells at very low doses of ionising radiation: spatial and temporal features. Radiat. Prot. Dosim. 166, 161-164 (2015), doi: 10.1093/rpd/ncv176
28.    Selmansberger M, A Feuchtinger, L Zurnadzhy, A Michna, J C Kaiser, M Abend, A Brenner, T Bogdanova, A Walch, K Unger, H Zitzelsberger and J Hess. CLIP2 as radiation biomarker in papillary thyroid carcinoma. Oncogene, (6 October 2014) | doi:10.1038/onc.2014.311
29.    Selmansberger M, Kaiser JC, Hess J, Guethlin D, Likhtarov I, Shpak V, et al. Dose-dependent expression of CLIP2 in post-Chernobyl papillary thyroid carcinomas. Carcinogenesis. 2015. doi: 10.1093/carcin/bgv043. PubMed PMID: 25957251
30.    Shim, G., Ricoul, M., Hempel WM, Azzam El, Sabatier L, Crosstalk between telomere maintenance and radiation effects: A key player in the process of radiation-induced carcinogenesis. Mutation Research, 2014, 1-17, doi: 10.1016/j.mrrev.2014.01.001
31.    Smirnova A, Gamba R, Khoriauli L, Vitelli V, Nergadze SG, Giulotto E. TERRA Expression Levels Do Not Correlate with Telomere Length and Radiation Sensitivity in Human Cancer Cell Lines. Front Oncol. 2013 May 10; 3:115.
32.    Vitelli V, Falvo P, Khoriauli L, Smirnova A, Gamba R, Santagostino M, Nergadze SG, Giulotto E. More on the Lack of Correlation between Terra Expression and Telomere Length. Front Oncol. 2013 Sep 18; 3:245. eCollection 2013
33.    Kaiser, Jan Christian, Reinhard Meckbach, Markus Eidemuller, Martin Selmansberger, Kristian Unger, Viktor Shpak, Maria Blettner, Horst Zitzelsbergerand Peter Jacob Integration of a radiation biomarker into modelling of thyroid carcinogenesis and post-Chernobyl risk assessment, , Carcinogenesis, 2016, Vol. 37, No. 12, 1152–1160, doi:10.1093/carcin/bgw102
34.    I. Zaballa, M. Eidemuller, Mechanistic study on lung cancer mortality after radon exposure in the Wismut cohort supports important role of clonal expansion in lung carcinogenesis., Radiat Environ Biophys (2016) 55:299–315, DOI 10.1007/s00411-016-0659-0
35.    S. Zöllner, M. E. Sokolnikov, and M. Eidemüller. (2015) Beyond two-stage models for lung carcinogenesis in the Mayak workers: Implications for Plutonium risk. PLOS ONE Published: May 22, 2015, https://doi.org/10.1371/journal.pone.0126238
36.    van Wieringen, W.N. & Peeters, C.F.W. (2016). Ridge estimation of inverse covariance matrices from high-dimensional data. Computational Statistics & Data Analysis, 103: 284-303. https://doi.org/10.1016/j.csda.2016.05.012


In press

1. Peeters, C.F.W., van de Wiel, M.A., & van Wieringen, W.N. (under review). The spectral condition number plot for regularization parameter determination

2. Bilgrau, A.E.*, Peeters, C.F.W.*, Eriksen, P.S., Boegsted, M., & van Wieringen, W.N. (revision under review at Journal of Machine Learning Research). Targeted fused ridge estimation of inverse covariance matrices from multiple high-dimensional data classes

In preparation

1. Liddle, D, McGuire ,A, Mariotti LG, Ottolenghi A, O’Neill P, Hill MA Generality of the modification of intercellular signalling following irradiation of normal human lung and breast epithelial cells and the role of oxidative stress.
2. Mariotti LG, Abdelrazzak A, Liddle, D, McGuire, A. Ottolenghi A, Vojnovic, B., O’Neill P, Hill MA Spatial and temporal features of apoptotic induction in pre-cancerous cells modulated by radiation.
3. Kundrát P et al, Low-dose radiation enhances the intercellular induction of apoptosis in oncogenic transformed cells in vitro but is predicted to reduce this anti-carcinogenic process in vivo
4. G. Babini, K. Unger, J. Morini, G. Baiocco, H. Zitzelsberger, A. Ottolenghi, Mechanisms of cytokine-mediated pro-apoptotic effects of irradiated normal cells on non-irradiated transformed cells.
5. Rubino C, Allodji R, Schvarz C, Andruccioli M, Bardet S, Henry-Amar M, Le Thai F, Corone K, Lönn S, Hall P, Lamart S, Diallo I, Ricard M, Schlumberger M, de Vathaire F. European cohort of Differentiated Thyroid Cancer (DTC): Risk of secondary breast cancer according to the treatments.
6. Sokolnikov M, Manuscript on breast cancer among Mayak workers
7. Anna Acheva, Siamak Haghdoost, Alice Sollazzo, Virpi Launonen and Meerit Kämäräinen, Presence of stromal cells enhances EMT induction in lung bronchial epithelium after protracted exposure to gamma radiation. Manuscript is ready for submission